ACTICLOT® dPT™, dilute Prothrombin Time test

Product Description

ACTICLOT® dPT™ is a dilute Prothrombin Time (dPT) test for the screening and confirmation of the presence of phospholipid-dependent Lupus Anticoagulant (LA) autoantibodies in plasma.

Some clinically significant LA preferentially manifest only in extrinsic pathways-based assays, such as dPT, and clinical studies have shown that ACTICLOT® dPT™ identifies LA in samples that are negative by APTT and dilute Russell’s Viper Venom Time (dRVVT) Tests1.

Recently published CSLI Guidelines (H60-A, April 2014) recognize the importance of looking at the various coagulation pathways for the detection of LA activity, including the extrinsic as well as the intrinsic and common pathways. Combining assays to cover all pathways increases the confidence in the diagnosis of Antiphospholipid Syndrome (APS).

During testing, clotting is initiated via the extrinsic coagulation pathway by tissue factor in the presence of calcium ions. Activation of the extrinsic pathway bypasses the intrinsic pathway excluding any interference from deficiencies of Factor XII.

Reagents are included for performing both a screening and confirmatory test. The presence of LA in plasma is identified when both tests are positive. The screening and confirmatory tests may be performed at the same time, allowing for the most rapid turnaround time for test results of each plasma. Alternatively, plasmas may first be screened for the presence of LA and then retested for confirmation of the phospholipid-dependence of the autoantibodies detected.

1Mackie I and Lawrie A; Evaluation of New Commercial Lupus Anticoagulant Reagents; data presented at the SSC Meeting of the ISTH, Venice, Italy, June 17-19, 2004

Features and Benefits

Advantages of ACTICLOT® dPT™

  • High specificity and high sensitivity provides confidence in results
  • Paired test which confirms a positive test with a unique, high phospholipid reagent, meeting CLSI recommendations
  • Picks up LA not identified by dRVVT and APTT tests
  • Easy to use – designed for use on automated coagulation analyzers; instrument applications are available
PRODUCT NAME REF # of tests
ACTICLOT® dPT™, dilute Prothrombin Time test 824 120 screening tests & 120 confirmatory tests per kit

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