A functional clotting assay for the quantitative determination of Protein S activity in human plasma.
Protein S is a Vitamin K dependent protein primarily synthesized in the liver, but also in the endothelium and possibly in megakaryocytes. It functions as a cofactor for activated Protein C in the inactivation of activated Factor V, and there is an association between thrombosis and Protein S deficiencies.
In the assay, dilutions of patient plasma are mixed with Protein S depleted plasma. Factor Xa, activated Protein C and phospholipids are added to the mixture, and finally calcium chloride is added to initiate clot formation. The prolongation of the clotting time is directly proportional to the concentration of Protein S in the patient’s plasma.
|PRODUCT NAME||REF||# of Tests|
|ACTICLOT® Protein S activity assay||843L||40|