Measures ADAMTS13 IgG autoantibodies in human plasma.
Studies have shown that low levels of ADAMTS13 activity are associated with Thrombotic Thrombocytopenia Purpura (TTP), a life-threatening hematological condition characterized by low platelet count, microvascular thrombi, red cell fragmentation, CNS and renal complications. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ADAMTS13 that inhibit its activity. The measurement of ADAMTS13 autoantibodies may provide information in researching acquired TTP and monitoring therapy.
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