Measures Free Protein S in human plasma.
Protein S is a Vitamin K dependent glycoprotein synthesized in the liver. In normal human plasma, Protein S is present in two forms: Free Protein S (40% of total Protein S concentration) and Protein S complexed with C4b binding protein (C4b-BP). Only Free Protein S is active and acts as a cofactor for activated Protein C in the inactivation of fVa and fVIIIa.
The determination of both Free Protein S and Total Protein S aids in the differential diagnosis of three types of Protein S deficiencies:
Type I – reduced levels of both Total and Free Protein S antigen
Type II – normal Total and Free Protein S antigen but reduced activity
Type III – normal Total Protein S levels but reduced Free Protein S levels.
This ELISA is not reactive with Protein S-C4b-BP complexes.
For Research Use Only
|PRODUCT NAME||REF||#of Tests|
|IMUCLONE™ Free Protein S ELISA||842||96|