Tissue Factor (TF) is a 45 kD transmembrane cell surface glycoprotein known for its role in initiating coagulation. TF is comprised of three domains: an extracellular domain (aa 1-219), followed by a hydrophilic spanning domain (aa 220-242) and a cytoplasmic tail (aa 243-263). It functions as a receptor and cofactor for the latent serine proteases factor VII and VIIa. Contact between TF and blood is sufficient to initiate the extrinsic pathway of coagulation.
|Recombinant Human Tissue Factor||4500||25 µg|